Last updated October 10th, 2021
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Averting an Outbreak of SARS-CoV-2 in a University Residence Hall through Wastewater Surveillance.

Corchis-Scott R, Geng Q, Seth R, Ray R, Beg M, Biswas N, Charron L, Drouillard KD, D’Souza R, Heath DD, Houser C, Lawal F, McGinlay J, Menard SL, Porter LA, Rawlings D, Scholl ML, Siu KWM, Tong Y, Weisener CG, Wilhelm SW, McKay RML.Microbiol Spectr. 2021 Oct 6:e0079221. doi: 10.1128/Spectrum.00792-21. Online ahead of print.PMID: 34612693 Free article.

The cyclin-like protein SPY1 overrides reprogramming induced senescence through EZH2 mediated H3K27me3.

Lubanska D, Qemo I, Byrne M, Matthews KN, Fifield BA, Brown J, da Silva EF, Porter LA.Stem Cells. 2021 Sep 6. doi: 10.1002/stem.3453. Online ahead of print.PMID: 34486784

Differential expression of glucose transporters and hexokinases in prostate cancer with a neuroendocrine gene signature: a mechanistic perspective for FDG imaging of PSMA-suppressed tumors

Bakht MK, Lovnicki JM, Tubman J, Stringer KF, Chiaramonte J, Reynolds MR, Derecichei I, Ferraiuolo RM, Fifield BA, Lubanska D, Oh SW, Cheon GJ, Kwak C, Jeong CW, Kang KW, Trant JF, Morrissey C, Coleman I, Wang Y, Ahmadzadehfar H, Dong X Porter LA
J Nucl Med 2020; 61:904–910 DOI: 10.2967/jnumed.119.231068.
[PDF 2.0 MB]

The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis

Fifield BA, Qemo I, Kirou E, Cardiff RD, Porter LA
Breast Cancer Res. 2019 Dec 11;21(1):140. doi: 10.1186/s13058-019-1211-3. [Epub ahead of print]
[PDF 9.0 MB]

Cyclin-Like Proteins Tip Regenerative Balance in the Liver to Favour Cancer Formation

Fifield BA, Talia J, Stoyanovich C, Elliott MJ, Bakht MK, Basilious A, Samsoondar JP, Curtis M, Stringer KF, Porter LA
Carcinogenesis. 2019 Oct 2. pii: bgz164. doi: 10.1093/carcin/bgz164. [Epub ahead of print]
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Neuro‐ and hepatic toxicological profile of (S)‐2,4‐diaminobutanoic acid in embryonic, adolescent and adult zebrafish

Ferraiuolo RM, Meister D, Leckie D, Dashti M, Franke J, Porter LA , Trant JF
J Appl Toxicol. 2019 Aug 6. doi: 10.1002/jat.3840. [Epub ahead of print]
[PDF 1.0 MB]

Transcriptomics Signature from Next-Generation Sequencing Data Reveals New Transcriptomic Biomarkers Related to Prostate Cancer

Alkhateeb A, Rezaeian I, Singireddy S, Cavallo-Medved D, Porter LA , Rueda L
Cancer Inform. 2019 Mar 13;18:1176935119835522. doi: 10.1177/1176935119835522. eCollection
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The Tuberin and Cyclin B1 complex functions as a novel G2/M sensor of serum conditions and Akt signaling

Fidalgo da Silva E, Botsford S, Dare-Shih J, Hanna MA, Porter LA
PLoS One. 2019 Jan 10;14(1):e0210612. doi: 10.1371/journal.pone.0210612. eCollection 2019
[PDF 1.4 MB]

Cell cycle dynamics in glioma cancer stem cells

Qemo I, Porter LA
Methods Mol Biol. 2019;1869:117-126. doi: 10.1007/978-1-4939-8805-1_11

Neuroendocrine differentiation of prostate cancer leads to PSMA suppression

Bakht MK, Derecichei I, Li Y, Ferraiuolo RM, Dunning M, Oh SW, Hussein A, Youn H, Stringer KF, Jeong CW, Cheon GJ, Kwak C, Kang KW, Lamb AD, Wang Y, Dong X, Porter LA
Endocr Relat Cancer. 2018 Nov 23;26(2):131-146. doi: 10.1530/ERC-18-0226
[PDF 6.3 MB]

Structural basis of divergent cyclin‐dependent kinase activation by Spy1/RINGO proteins

Denise A McGrath, Bre‐Anne Fifield, Aimee H Marceau, Sarvind Tripathi, Lisa A. Porter, Seth M Rubin
The EMBO Journal (2017). DOI 10.15252/embj.201796905
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Revisiting CDK Inhibitors for Treatment of Glioblastoma Multiforme

Dorota Lubanska, Lisa A. Porter
Drugs R D (2017). doi:10.1007/s40268-017-0180-1
[PDF 2.0 MB]

The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance

Rosa-Maria Ferraiuolo, Janice Tubman, Indrajit Sinha, Caroline Hamm, Lisa Ann Porter
Oncotarget (2017) DOI: 10.18632/oncotarget.15578
[PDF 2.0 MB]

The potential roles of radionanomedicine and radioexosomic in prostate cancer research and treatment.

Martin K. Bakht, So Won Oh, Do Won Hwang, Yun-Sang Lee, Hyewon Youn, Lisa A. Porter, Gi Jeong Cheon, Cheol Kwak, Dong Soo Lee, Keon Wook Kang.
Curr Pharm Des. 2017 Feb 16. doi: 10.2174/1381612823666170216122412.

Activated thrombin-activatable fibrinolysis inhibitor attenuates the angiogenic potential of endothelial cells: potential relevance to the breast tumour microenvironment

Zainab A. Bazzi, Jennifer Balun, Dora Cavallo-Medved, Lisa A. Porter, Michael B. Boffa
Clin Exp Metastasis (2017) 34: 155. doi:10.1007/s10585-017-9837-y
[PDF 2.0 MB]

TAFIa is a Novel Inhibitor of Tumour Angiogenesis in Breast Cancer.

B Balun, ZA Bazzi, D Cavallo-Medved, LA Porter and MB Boffa.
BMC Cancer 2016 24 16(1):328.  Funded by S4H (Boffa – PI).
[PDF 2.0 MB]

A Model used to Detect Differential Splice Junctions as Biomarkers in Prostate Cancer from RNA-seq Data.

I Rezaeian, A Tavakoli, D Cavallo-Medved, LA Porter, L Rueda.
Journal of Biomedical Informatics 2016 60:422-30.  Funded by S4H (Rueda – PI).
[PDF 1.6 MB]

Direct Interactions with both p27 and Cdk2 regulate Spy1-mediated proliferation in vivo and in vitro. 

Mohammad Al Sorkhy, Bre-Anne Fifield, Dorothy Myers, Lisa A Porter.
Cell Cycle 2016 15 (1): 128-136
[PDF 1.0 MB]

Derivation of a novel G2 reporter system.

Elizabeth Fidalgo da Silva, Sabrina Botsford, Lisa A Porter.
Cytotechnology 2016 (1): 19 – 24
[PDF 0.9 MB]

Sodium salicylate reduces the level of GABAB receptors in the rat's inferior colliculus. 

S Butt, F Ashraf, Lisa A Porter, H Zhang.
Neuroscience.  2016 Jan 4.
PMID: 26705739

Paclitaxel-induced transcriptional regulation of Fas signaling pathway is antagonized by dexamethasone.

Martin Crozier, Lisa A Porter.
Breast Cancer Res. Treat. 2015 Oct 13. [Epub ahead of print]
PMID: 26463651

[PDF 1.1MB]

The atypical cell cycle regulator Spy1 suppresses differentiation of the neuroblastoma stem cell population.

Dorota Lubanska, Lisa A Porter.
Oncoscience 2014 1 (5): 336–348


The cyclin-like protein Spy1 regulates growth and division characteristics of the CD133+ population in human glioma.

Dorota Lubanska, Brenna A Market-Velker, Ana C deCarvalho, Tom Mikkelsen, Elizabeth Fidalgo da Silva, Lisa A Porter.
Cancer Cell 2014 25 (1): 64–76
doi: http://dx.doi.org/10.1016/j.ccr.2013.12.006
Highlighted in Cancer Discovery 2014 4: OF11 doi:10.1158/2159-8290.CD-RW2014-025
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The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer.

Mohammad Al Sorkhy, Rosa-Maria Ferraiuolo, Espanta Jalili, Agnes Malysa, Andreea R Fratiloiu, Bonnie F Sloane, Lisa A Porter.
BMC Cancer 2012 25 (45)
[PDF 4.6MB]

pH effects on bio-permeability of natural rubber latex polymers.

Janice Tubman, Jiamila Maimaiti, Maher El Masri, Susan Fox-Wasylyshyn, Debbie Kane, Trinh TX Nguyen, Eleanor Maticka-Tyndale, Lisa A Porter.
American Journal of Biomedical Sciences 2011 3 (4): 292–300
doi: 10.5099/aj110400292
[PDF 391KB]

The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1.

Elizabeth Fidalgo da Silva, Shora B Ansari, Jiamila Maimaiti, Elizabeth A Barnes, Monica Kong-Beltran, Daniel J Donoghue, Lisa A Porter.
Cell Cycle 2011 10 (18): 3129–39
doi: 10.4161/cc.10.18.17296
[PDF 3.4MB]

The level and distribution of the GABA(B)R2 receptor subunit in the rat's central auditory system.

Lena Jamal , Hao Zhang, Paul G Finlayson , Lisa A Porter, Huiming Zhang.
Neuroscience 2011 181 (5): 243–56
doi: http://dx.doi.org/10.1016/j.neuroscience.2011.02.050

The cyclin-dependant kinase activator, Spy1A, is targeted for degradation by the ubiquitin ligase NEDD4.

Mohammad Al Sorkhy, Ryan Craig, Brenna Market, Ryan Ard, Lisa A Porter.
Journal of Biological Chemistry 2009 284 (5): 2617–27
[PDF 1.4MB]

The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis.

Azadeh Golipour, Dorothy Myers, Tiffany Seagroves, Daniel Murphy, Gerard I Evan, Daniel J Donoghue, Roger A Moorehead, Lisa A Porter.
Cancer Research 2008 68 (10): 3591–3600
doi: 10.1158/0008-5472.CAN-07-6453
[PDF 852KB]

Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27.

Christopher W McAndrew, Randy F Gastwirt, April N Meyer, Lisa A Porter, Daniel J Donoghue.
Cell Cycle 2007 6 (15): 1937-45
doi: 10.4161/cc.6.15.4520
[PDF 913KB]

Spy1 interacts with p27Kip1 to allow G1/S progression.

Lisa A Porter, Monica Kong-Beltran, Daniel J Donoghue.
Molecular Biology of the Cell 2003 14 (9): 3664-74
doi: 10.1091/mbc.E02-12-0820
[PDF 455KB]

Human Spy1 promotes survival of mammalian cells following DNA damage.

Elizabeth A Barnes, Lisa A Porter, Jean-Luc Lenormand, Ryan W Dellinger, Daniel J Donoghue.
Cancer Research 2003 63 (13): 3701–07
[PDF 283KB]

Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis.

Lisa A Porter, Howard Cukier, Jonathan M Lee.
Blood 2003 101 (5): 1928–33
doi: 10.1182/blood-2002-04-1103
[PDF 680KB]

Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.

Nisha Anand, Sabita Murthy, Gudrun Amann, Meredith Wernick, Lisa A Porter, I Howard Cukier, Colin Collins, Joe W Gray, Joachim Diebold, Doug J Demetrick, Jonathan M Lee.
Nature Genetics 2002 31 (3): 301-5

Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2.

Lisa A Porter, Ryan W Dellinger, John A Tynan, Elizabeth A Barnes, Monica Kong, Jean-Luc Lenormand, Daniel J Donoghue.
Journal of Cell Biology 2002 157 (3): 357–66
doi: 10.1083/jcb.200109045
[PDF 360KB]

alpha-, beta-, and gamma-Tubulin polymerization in response to DNA damage.

Lisa A Porter & Jonathan M Lee.
Experimental Cell Research 2001 270 (2): 151–8
doi: http://dx.doi.org/10.1006/excr.2001.5322

Abundance of cyclin B1 regulates gamma-radiation-induced apoptosis.

Lisa A Porter, Gurmit Singh, Jonathan M Lee.
Blood 2000 95 (8): 2645–50
[PDF 184KB]


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