Structural basis of divergent cyclin‐dependent kinase activation by Spy1/RINGO proteins
Denise A McGrath, Bre‐Anne Fifield, Aimee H Marceau, Sarvind Tripathi, Lisa A. Porter, Seth M Rubin
The EMBO Journal (2017). DOI 10.15252/embj.201796905
[PDF 2.0 MB]

Revisiting CDK Inhibitors for Treatment of Glioblastoma Multiforme
Dorota Lubanska, Lisa A. Porter
Drugs R D (2017). doi:10.1007/s40268-017-0180-1
[PDF 2.0 MB]

The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance
Rosa-Maria Ferraiuolo, Janice Tubman, Indrajit Sinha, Caroline Hamm, Lisa Ann Porter
Oncotarget (2017) DOI: 10.18632/oncotarget.15578
[PDF 2.0 MB]

The potential roles of radionanomedicine and radioexosomic in prostate cancer research and treatment.
Martin K. Bakht, So Won Oh, Do Won Hwang, Yun-Sang Lee, Hyewon Youn, Lisa A. Porter, Gi Jeong Cheon, Cheol Kwak, Dong Soo Lee, Keon Wook Kang.
Curr Pharm Des. 2017 Feb 16. doi: 10.2174/1381612823666170216122412.

Activated thrombin-activatable fibrinolysis inhibitor attenuates the angiogenic potential of endothelial cells: potential relevance to the breast tumour microenvironment
Zainab A. Bazzi, Jennifer Balun, Dora Cavallo-Medved, Lisa A. Porter, Michael B. Boffa
Clin Exp Metastasis (2017) 34: 155. doi:10.1007/s10585-017-9837-y
[PDF 2.0 MB]


TAFIa is a Novel Inhibitor of Tumour Angiogenesis in Breast Cancer.
B Balun, ZA Bazzi, D Cavallo-Medved, LA Porter and MB Boffa.
BMC Cancer 2016 24 16(1):328.  Funded by S4H (Boffa – PI).
[PDF 2.0 MB]

Bio Informatics

A Model used to Detect Differential Splice Junctions as Biomarkers in Prostate Cancer from RNA-seq Data.
I Rezaeian, A Tavakoli, D Cavallo-Medved, LA Porter, L Rueda.
Journal of Biomedical Informatics 2016 60:422-30.  Funded by S4H (Rueda – PI).
[PDF 1.6 MB]

Direct Interactions with both p27 and Cdk2 regulate Spy1-mediated proliferation in vivo and in vitro
Mohammad Al Sorkhy, Bre-Anne Fifield, Dorothy Myers, Lisa A Porter.
Cell Cycle 2016 15 (1): 128-136
[PDF 1.0 MB]

Derivation of a novel G2 reporter system.
Elizabeth Fidalgo da Silva, Sabrina Botsford, Lisa A Porter.
Cytotechnology 2016 (1): 19 – 24
[PDF 0.9 MB]


Sodium salicylate reduces the level of GABAB receptors in the rat’s inferior colliculus. 
S Butt, F Ashraf, Lisa A Porter, H Zhang.
Neuroscience.  2016 Jan 4.
PMID: 26705739

 breast cancer research and treatment journal article image

Paclitaxel-induced transcriptional regulation of Fas signaling pathway is antagonized by dexamethasone.
Martin Crozier, Lisa A Porter.
Breast Cancer Res. Treat. 2015 Oct 13. [Epub ahead of print]
PMID: 26463651

[PDF 1.1MB]

The atypical cell cycle regulator Spy1 suppresses differentiation of the neuroblastoma stem cell population.
Dorota Lubanska, Lisa A Porter.
Oncoscience 2014 1 (5): 336–348


The cyclin-like protein Spy1 regulates growth and division characteristics of the CD133+ population in human glioma.
Dorota Lubanska, Brenna A Market-Velker, Ana C deCarvalho, Tom Mikkelsen, Elizabeth Fidalgo da Silva, Lisa A Porter.
Cancer Cell 2014 25 (1): 64–76
Hightlighted in Cancer Discovery 2014 4: OF11 doi:10.1158/2159-8290.CD-RW2014-025
[PDF 3.1MB]

The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer.
Mohammad Al Sorkhy, Rosa-Maria Ferraiuolo, Espanta Jalili, Agnes Malysa, Andreea R Fratiloiu, Bonnie F Sloane, Lisa A Porter.
BMC Cancer 2012 25 (45)
[PDF 4.6MB]

pH effects on bio-permeability of natural rubber latex polymers.
Janice Tubman, Jiamila Maimaiti, Maher El Masri, Susan Fox-Wasylyshyn, Debbie Kane, Trinh TX Nguyen, Eleanor Maticka-Tyndale, Lisa A Porter.
American Journal of Biomedical Sciences 2011 3 (4): 292–300
doi: 10.5099/aj110400292
[PDF 391KB]

The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1.
Elizabeth Fidalgo da Silva, Shora B Ansari, Jiamila Maimaiti, Elizabeth A Barnes, Monica Kong-Beltran, Daniel J Donoghue, Lisa A Porter.
Cell Cycle 2011 10 (18): 3129–39
doi: 10.4161/cc.10.18.17296
[PDF 3.4MB]

The level and distribution of the GABA(B)R2 receptor subunit in the rat’s central auditory system.
Lena Jamal , Hao Zhang, Paul G Finlayson , Lisa A Porter, Huiming Zhang.
Neuroscience 2011 181 (5): 243–56

The cyclin-dependant kinase activator, Spy1A, is targeted for degradation by the ubiquitin ligase NEDD4.
Mohammad Al Sorkhy, Ryan Craig, Brenna Market, Ryan Ard, Lisa A Porter.
Journal of Biological Chemistry 2009 284 (5): 2617–27
[PDF 1.4MB]

The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis.
Azadeh Golipour, Dorothy Myers, Tiffany Seagroves, Daniel Murphy, Gerard I Evan, Daniel J Donoghue, Roger A Moorehead, Lisa A Porter.
Cancer Research 2008 68 (10): 3591–3600
doi: 10.1158/0008-5472.CAN-07-6453
[PDF 852KB]

Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27.
Christopher W McAndrew, Randy F Gastwirt, April N Meyer, Lisa A Porter, Daniel J Donoghue.
Cell Cycle 2007 6 (15): 1937-45
doi: 10.4161/cc.6.15.4520
[PDF 913KB]

Spy1 interacts with p27Kip1 to allow G1/S progression.
Lisa A Porter, Monica Kong-Beltran, Daniel J Donoghue.
Molecular Biology of the Cell 2003 14 (9): 3664-74
doi: 10.1091/mbc.E02-12-0820
[PDF 455KB]

Human Spy1 promotes survival of mammalian cells following DNA damage.
Elizabeth A Barnes, Lisa A Porter, Jean-Luc Lenormand, Ryan W Dellinger, Daniel J Donoghue.
Cancer Research 2003 63 (13): 3701–07
[PDF 283KB]

Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis.
Lisa A Porter, Howard Cukier, Jonathan M Lee.
Blood 2003 101 (5): 1928–33
doi: 10.1182/blood-2002-04-1103
[PDF 680KB]

Cyclin B1 and CDK1: nuclear localization and upstream regulators.
Lisa A Porter & Daniel J Donoghue.
In L. Meijer, A. Jezequel & M. Roberge (Eds.), Progress in Cell Cycle Research Vol. 5 2003: 335–47
Roscoff: New York..

Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.
Nisha Anand, Sabita Murthy, Gudrun Amann, Meredith Wernick, Lisa A Porter, I Howard Cukier, Colin Collins, Joe W Gray, Joachim Diebold, Doug J Demetrick, Jonathan M Lee.
Nature Genetics 2002 31 (3): 301-5

Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2.
Lisa A Porter, Ryan W Dellinger, John A Tynan, Elizabeth A Barnes, Monica Kong, Jean-Luc Lenormand, Daniel J Donoghue.
Journal of Cell Biology 2002 157 (3): 357–66
doi: 10.1083/jcb.200109045
[PDF 360KB]

alpha-, beta-, and gamma-Tubulin polymerization in response to DNA damage.
Lisa A Porter & Jonathan M Lee.
Experimental Cell Research 2001 270 (2): 151–8

Abundance of cyclin B1 regulates gamma-radiation-induced apoptosis.
Lisa A Porter, Gurmit Singh, Jonathan M Lee.
Blood 2000 95 (8): 2645–50
[PDF 184KB]