Stephanie Dinescu Glioblastoma (GBM) is the most frequent and aggressive primary malignant brain tumour. Despite rigorous therapeutic efforts, the prognosis of GBM remains extremely low, with a median survival of approximately 14 months after diagnosis. Our lab studies a cyclin-like protein called Spy1 which has been found to be elevated in GBM. Spy1 overrides cell-cycle checkpoints …
Amy Llancari My project focuses on differentiating the progression of Non-alcoholic Fatty Liver Disease (NALFD) into Hepatocellular Carcinoma (HCC) between male and female mice. HCC is the sixth most prevalent cancer in the world, yet it ranks as the third leading type of cancer deaths with an accelerated increase in incidence rates. NAFLD is a …
Tiana Visconti Determining the Dependency of Spy1 based on Rb Status in Triple Negative Breast Cancer Breast cancer is the second most common cancer worldwide and the most common cancer among women. Triple Negative Breast Cancer (TNBC) is a particularly aggressive form of breast cancer with many subtypes based on gene expression profiles. There …
Ali Nadi Applying CRISPR/Cas9 and Fluorescent Tools to Dissect the Role of Tuberin in Cell Cycle Regulation How cells regulate their growth and division involves a tightly controlled integration of many mechanisms. In cells, Tuberin (gene – TSC2) is a protein in the Tuberous Sclerosis Complex (TSC) which modulates cellular growth, size, and proliferation. Mutations in …
Undergrads Students 2022
During our lab meeting today one of our graduate students, Isabelle Hinch, presented a great seminar about Mental Health in Academia. Academic life, for both faculty and students, has always been stressful, but the pandemic has made it worse. In her presentation, Isabelle share resources that can help to deal with the insecurities and stress …
Two of our awesome undergraduate students are sharing their projects and experiences during their time in our lab. Check here to read the first post about our 2021 undergraduate students. Evaluation of the cell cycle regulation in Tuberin knockout cell lines Tuberin (TSC2) and its binding partner hamartin (TSC1) are tumour suppressor proteins that regulate …
Our 2021 undergraduate students have done wonderful work presenting their research results at the Ontario Biology Day, UWill Discover, and our Undergraduate Research Colloquium. Our lab has faced many challenges during this past year, the pandemic has tested our limits in many ways, but we are keeping up with our outstanding research projects. We had …
Producer and Director – Our fabulous graduate student Isabelle Hinch.
Our video today features Frank, a Ph.D. student in our lab. He calls himself ‘Chartreuse man’ and shows us how he is keeping fit during the quarantine. If you are curious to know what is Chartreuse you must watch this video! Just in case you missed, below are the previous videos: Part 1 – Lisa and …
