Last updated Sept 13, 2023

Actionable wastewater surveillance: application to a university residence hall during the transition between Delta and Omicron resurgences of COVID-19

Ryland Corchis-Scott Qiudi Geng Abdul Monem Al Riahi Amr Labak Ana Podadera Kenneth K S Ng Lisa A Porter Yufeng Tong Jess C Dixon Sherri Lynne Menard Rajesh Seth R Michael McKay 

Front. Public Health, 17 May 2023
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 11 – 2023 | doi.org/10.3389/fpubh.2023.1139423


Tuberin levels during cellular differentiation in brain development

Elizabeth Fidalgo da Silva, Bashaer Abu Khatir+, Christopher Drouillard+, Isabelle Hinch+, Gordon Omar Davis, Mariam Sameem, Rutu Patel, Jackie Fong, Dorota Lubanska, and Lisa A. Porter.

+ Contributed equally, listed in alphabetical order

Differentiation 2023  March–April Vol 130  Pages 43-50 doi.org/10.1016/j.diff.2022.12.004


Frequently used antiemetic agent dexamethasone enhances the metastatic behaviour of select breast cancer cells

Crozier M, Tubman J, Fifield BA, Ferraiuolo RM, Ritchie J, Zuccato K, Mailloux E, Sinha I, Hamm C, Porter LA.

PLoS One. 2022 Sep 15;17(9):e0274675. doi: 10.1371/journal.pone.0274675. eCollection 2022.PMID: 36107918 


Stabilization of c-Myc by the atypical cell cycle regulator, Spy1, decreases efficacy of breast cancer treatments

Ferraiuolo RM, Fifield BA, Hamm C, Porter LA.

Breast Cancer Res Treat. 2022 Nov;196(1):17-30. doi: 10.1007/s10549-022-06715-z. Epub 2022 Aug 27.PMID: 36029387


Dissecting the roles of the Tuberin protein in the subcellular localization of the G2/M Cyclin, Cyclin B1

A. Pillon, J. Dare-Shih, J. Fong, E. Fidalgo da Silva, and L. A. Porter

PLoS One 2022 Aug 10;17(8):e0272741. doi: 10.1371/journal.pone.0272741.   – NSERC funded


Impairing proliferation of glioblastoma multiforme with CD44+ selective conjugated polymer nanoparticles

Lubanska D, Alrashed S, Mason GT, Nadeem F, Awada A, DiPasquale M, Sorge A, Malik A, Kojic M, Soliman MAR, deCarvalho AC, Shamisa A, Kulkarni S, Marquardt D, Porter LA, Rondeau-Gagné S.

Sci Rep. 2022 Jul 15;12(1):12078. doi: 10.1038/s41598-022-15244-0.PMID: 35840697 

Fitted filtration efficiency and breathability of 2-ply cotton masks: Identification of cotton consumer categories acceptable for home-made cloth mask construction

Drouillard KG, Tomkins A, Lackie S, Laengert S, Baker A, Clase CM, De Lannoy CF, Cavallo-Medved D, Porter LA, Rudman RS.

PLoS One. 2022 Mar 22;17(3):e0264090. doi: 10.1371/journal.pone.0264090. eCollection 2022.PMID: 35316263

A prospective phase II clinical trial identifying the optimal regimen for carboplatin plus standard backbone of anthracycline and taxane-based chemotherapy in triple negative breast cancer

Hamm C, Fifield BA, Kay A, Kulkarni S, Gupta R, Mathews J, Ferraiuolo RM, Al-Wahsh H, Mailloux E, Hussein A, Porter LA.

Med Oncol. 2022 Feb 1;39(4):49. doi: 10.1007/s12032-021-01637-0.PMID: 35103812 

Clinical Trial

Identification of alternative protein targets of glutamate-ureido-lysine associated with PSMA tracer uptake in prostate cancer cells

Bakht MK, Hayward JJ, Shahbazi-Raz F, Skubal M, Tamura R, Stringer KF, Meister D, Venkadakrishnan VB, Xue H, Pillon A, Stover M, Tronchin A, Fifield BA, Mader L, Ku SY, Cheon GJ, Kang KW, Wang Y, Dong X, Beltran H, Grimm J, Porter LA, Trant JF.

Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2025710119.

doi: 10.1073/pnas.2025710119.PMID: 35064078 


Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation

E. Fidalgo da Silva, J. Fong, A. Roye-Azar, A. Nadi, C. Drouillard, A. Pillon and L. A. Porter

Front. Cell Dev. Biol., 14 January 2022 | https://doi.org/10.3389/fcell.2021.806521  – NSERC funded


A retrospective single center study investigating the clinical significance of grade in triple negative breast cancer.

S. Upneja, A. Hussein, D. Moudgil, S. Kulkarni, R. Gupta, A. Kay, LA. Porter, B. Fifield, R. Ferraiuolo and C. Hamm. (2022)

Cancer Studies and Therapeutics (#2002-7184 in press).

Barriers to translational research in Windsor Ontario: A survey of clinical care providers and health researchers

JB Senecal, K Metcalfe, K Wilson, I Woldie and LA. Porter.

 Journal of Translational Medicine. 2021 Nov; 19(1):479. 


Averting an Outbreak of SARS-CoV-2 in a University Residence Hall through Wastewater Surveillance.

Corchis-Scott R, Geng Q, Seth R, Ray R, Beg M, Biswas N, Charron L, Drouillard KD, D’Souza R, Heath DD, Houser C, Lawal F, McGinlay J, Menard SL, Porter LA, Rawlings D, Scholl ML, Siu KWM, Tong Y, Weisener CG, Wilhelm SW, McKay RML.

Microbiol Spectr. 2021 Oct 6:e0079221. doi: 10.1128/Spectrum.00792-21. Online ahead of print.PMID: 34612693 Free article.

The cyclin-like protein SPY1 overrides reprogramming induced senescence through EZH2 mediated H3K27me3.

Lubanska D, Qemo I, Byrne M, Matthews KN, Fifield BA, Brown J, da Silva EF, Porter LA.Stem Cells. 2021 Sep 6. doi: 10.1002/stem.3453. Online ahead of print.PMID: 34486784

Differential expression of glucose transporters and hexokinases in prostate cancer with a neuroendocrine gene signature: a mechanistic perspective for FDG imaging of PSMA-suppressed tumors

Bakht MK, Lovnicki JM, Tubman J, Stringer KF, Chiaramonte J, Reynolds MR, Derecichei I, Ferraiuolo RM, Fifield BA, Lubanska D, Oh SW, Cheon GJ, Kwak C, Jeong CW, Kang KW, Trant JF, Morrissey C, Coleman I, Wang Y, Ahmadzadehfar H, Dong X Porter LA
J Nucl Med 2020; 61:904–910 DOI: 10.2967/jnumed.119.231068. Featured Article June 2020

[PDF 2.0 MB]

The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis

Fifield BA, Qemo I, Kirou E, Cardiff RD, Porter LA
Breast Cancer Res. 2019 Dec 11;21(1):140. doi: 10.1186/s13058-019-1211-3. [Epub ahead of print]
[PDF 9.0 MB]

Cyclin-Like Proteins Tip Regenerative Balance in the Liver to Favour Cancer Formation

Fifield BA, Talia J, Stoyanovich C, Elliott MJ, Bakht MK, Basilious A, Samsoondar JP, Curtis M, Stringer KF, Porter LA Carcinogenesis 2020 Jul 10;41(6):850-862.

[PDF 2.0 MB]

Neuro‐ and hepatic toxicological profile of (S)‐2,4‐diaminobutanoic acid in embryonic, adolescent and adult zebrafish

Ferraiuolo RM, Meister D, Leckie D, Dashti M, Franke J, Porter LA , Trant JF
J Appl Toxicol. 2019 Aug 6. doi: 10.1002/jat.3840. [Epub ahead of print]
[PDF 1.0 MB]

Transcriptomics Signature from Next-Generation Sequencing Data Reveals New Transcriptomic Biomarkers Related to Prostate Cancer

Alkhateeb A, Rezaeian I, Singireddy S, Cavallo-Medved D, Porter LA , Rueda L
Cancer Inform. 2019 Mar 13;18:1176935119835522. doi: 10.1177/1176935119835522. eCollection
[PDF 1.0 MB]

The Tuberin and Cyclin B1 complex functions as a novel G2/M sensor of serum conditions and Akt signaling

Fidalgo da Silva E, Botsford S, Dare-Shih J, Hanna MA, Porter LA
PLoS One. 2019 Jan 10;14(1):e0210612. doi: 10.1371/journal.pone.0210612. eCollection 2019
[PDF 1.4 MB]

Cell cycle dynamics in glioma cancer stem cells

Qemo I, Porter LA
Methods Mol Biol. 2019;1869:117-126. doi: 10.1007/978-1-4939-8805-1_11

Neuroendocrine differentiation of prostate cancer leads to PSMA suppression

Bakht MK, Derecichei I, Li Y, Ferraiuolo RM, Dunning M, Oh SW, Hussein A, Youn H, Stringer KF, Jeong CW, Cheon GJ, Kwak C, Kang KW, Lamb AD, Wang Y, Dong X, Porter LA
Endocr Relat Cancer. 2018 Nov 23;26(2):131-146. doi: 10.1530/ERC-18-0226 Editor’s Choice – Paper of 2019

[PDF 6.3 MB]

Structural basis of divergent cyclin‐dependent kinase activation by Spy1/RINGO proteins

Denise A McGrath, Bre‐Anne Fifield, Aimee H Marceau, Sarvind Tripathi, Lisa A. Porter, Seth M Rubin
The EMBO Journal (2017). DOI 10.15252/embj.201796905
[PDF 2.0 MB]

An Integrative Approach for Identifying Network Biomarkers of Breast Cancer Subtypes Using Genomics, Interactomics and Transcriptomics Data

F Firoozbakht, I Rezaeian, M D’agnilloz, LA Porter, L Rueda and A Ngom. 

Journal of Computational Biology 2017 24(8):756-766. 


Revisiting CDK Inhibitors for Treatment of Glioblastoma Multiforme

Dorota Lubanska, Lisa A. Porter
Drugs R D (2017). doi:10.1007/s40268-017-0180-1
[PDF 2.0 MB]

The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance

Rosa-Maria Ferraiuolo, Janice Tubman, Indrajit Sinha, Caroline Hamm, Lisa Ann Porter
Oncotarget (2017) DOI: 10.18632/oncotarget.15578
[PDF 2.0 MB]

The potential roles of radionanomedicine and radioexosomic in prostate cancer research and treatment.

Martin K. Bakht, So Won Oh, Do Won Hwang, Yun-Sang Lee, Hyewon Youn, Lisa A. Porter, Gi Jeong Cheon, Cheol Kwak, Dong Soo Lee, Keon Wook Kang.
Curr Pharm Des. 2017 Feb 16. doi: 10.2174/1381612823666170216122412.

Activated thrombin-activatable fibrinolysis inhibitor attenuates the angiogenic potential of endothelial cells: potential relevance to the breast tumour microenvironment

Zainab A. Bazzi, Jennifer Balun, Dora Cavallo-Medved, Lisa A. Porter, Michael B. Boffa
Clin Exp Metastasis (2017) 34: 155. doi:10.1007/s10585-017-9837-y
[PDF 2.0 MB]

TAFIa is a Novel Inhibitor of Tumour Angiogenesis in Breast Cancer.

B Balun, ZA Bazzi, D Cavallo-Medved, LA Porter and MB Boffa.
BMC Cancer 2016 24 16(1):328.  Funded by S4H (Boffa – PI).
[PDF 2.0 MB]

A Model used to Detect Differential Splice Junctions as Biomarkers in Prostate Cancer from RNA-seq Data.

I Rezaeian, A Tavakoli, D Cavallo-Medved, LA Porter, L Rueda.
Journal of Biomedical Informatics 2016 60:422-30.  Funded by S4H (Rueda – PI).
[PDF 1.6 MB]

Direct Interactions with both p27 and Cdk2 regulate Spy1-mediated proliferation in vivo and in vitro. 

Mohammad Al Sorkhy, Bre-Anne Fifield, Dorothy Myers, Lisa A Porter.
Cell Cycle 2016 15 (1): 128-136 Topic of Editorial review. Dewhurst and Kaldis.  

[PDF 1.0 MB]

Derivation of a novel G2 reporter system.

Elizabeth Fidalgo da Silva, Sabrina Botsford, Lisa A Porter.
Cytotechnology 2016 (1): 19 – 24
[PDF 0.9 MB]

Sodium salicylate reduces the level of GABAB receptors in the rat's inferior colliculus. 

S Butt, F Ashraf, Lisa A Porter, H Zhang.
Neuroscience.  2016 Jan 4.
PMID: 26705739

Paclitaxel-induced transcriptional regulation of Fas signaling pathway is antagonized by dexamethasone.

Martin Crozier, Lisa A Porter.
Breast Cancer Res. Treat. 2015 Oct 13. [Epub ahead of print]
PMID: 26463651

[PDF 1.1MB]

Effect of media on biofilter performance following ozonation of secondary treated municipal wastewater effluent: Sand vs. GAC.

MJ Reaume, R Seth, KN McPhedran, E Fidalgo da Silva and LA Porter.

Ozone: Science & Engineering 2015 37(2): 143-153. Funded by NSERC

[PDF 395 KB] 

Atypical Cell Cycle Control over Neural Cell Fate.

Dorota Lubanska, Lisa A Porter.

Cell Cycle 2014 13 (19): 2987-8 ISI Impact – 5.423.  Funded by CCSRI. PMID:25486555 

[PDF 38KB]

The atypical cell cycle regulator Spy1 suppresses differentiation of the neuroblastoma stem cell population.

Dorota Lubanska, Lisa A Porter.
Oncoscience 2014 1 (5): 336–348 –Inaugural edition; cover selection

 [PDF 2MB]

  • Commented on: Podkowa M, Irwin MS. (2014) Oncotarget. 5(15):5848-9. Editorial: Spy’ing on Differentiation in Neuroblastoma. PMID: 25109839 
  • Commented on: Bisteau X,  Kaldis P. Oncotarget. (2014) Aug 30;5(16):6554-5.  Editorial : Spy1/SpeedyA accelerates neuroblastoma. PMID: 25216512 
  • Commented on: Parvez Vora, Chitra Venugopal and Sheila K. Singh (2014) Oncotarget 5(22): 11014-11016  Revealed: The spy who regulates neuroblastoma stem cells. 

The cyclin-like protein Spy1 regulates growth and division characteristics of the CD133+ population in human glioma.

Dorota Lubanska, Brenna A Market-Velker, Ana C deCarvalho, Tom Mikkelsen, Elizabeth Fidalgo da Silva, Lisa A Porter.
Cancer Cell 2014 25 (1): 64–76
doi: http://dx.doi.org/10.1016/j.ccr.2013.12.006
Highlighted in Cancer Discovery 2014 4: OF11 doi:10.1158/2159-8290.CD-RW2014-025
[PDF 3.1MB]

  • Highlighted in Cancer Discovery March 2014 doi:10.1158/2159-8290.CD-RW2014-025.  
  • Commented on:  Parry PV and Engh JA Editorial Neurosurgery. (2014)  Jun;74(6):N18-9. doi: 10.1227/01.neu.0000450235.91492.8f  PMID: 24836103 
  • Recommended by F1000Prime. 
  • Highlighted in Cancer Research (2014) 74:977.  

The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer.

Mohammad Al Sorkhy, Rosa-Maria Ferraiuolo, Espanta Jalili, Agnes Malysa, Andreea R Fratiloiu, Bonnie F Sloane, Lisa A Porter.
BMC Cancer 2012 25 (45)
[PDF 4.6MB]

pH effects on bio-permeability of natural rubber latex polymers.

Janice Tubman, Jiamila Maimaiti, Maher El Masri, Susan Fox-Wasylyshyn, Debbie Kane, Trinh TX Nguyen, Eleanor Maticka-Tyndale, Lisa A Porter.
American Journal of Biomedical Sciences 2011 3 (4): 292–300
doi: 10.5099/aj110400292
[PDF 391KB]

The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1.

Elizabeth Fidalgo da Silva, Shora B Ansari, Jiamila Maimaiti, Elizabeth A Barnes, Monica Kong-Beltran, Daniel J Donoghue, Lisa A Porter.
Cell Cycle 2011 10 (18): 3129–39
doi: 10.4161/cc.10.18.17296
[PDF 3.4MB]

The level and distribution of the GABA(B)R2 receptor subunit in the rat's central auditory system.

Lena Jamal , Hao Zhang, Paul G Finlayson , Lisa A Porter, Huiming Zhang.
Neuroscience 2011 181 (5): 243–56
doi: http://dx.doi.org/10.1016/j.neuroscience.2011.02.050

The cyclin-dependant kinase activator, Spy1A, is targeted for degradation by the ubiquitin ligase NEDD4.

Mohammad Al Sorkhy, Ryan Craig, Brenna Market, Ryan Ard, Lisa A Porter.
Journal of Biological Chemistry 2009 284 (5): 2617–27
[PDF 1.4MB]

The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis.

Azadeh Golipour, Dorothy Myers, Tiffany Seagroves, Daniel Murphy, Gerard I Evan, Daniel J Donoghue, Roger A Moorehead, Lisa A Porter.
Cancer Research 2008 68 (10): 3591–3600
doi: 10.1158/0008-5472.CAN-07-6453
[PDF 852KB]

Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27.

Christopher W McAndrew, Randy F Gastwirt, April N Meyer, Lisa A Porter, Daniel J Donoghue.
Cell Cycle 2007 6 (15): 1937-45
doi: 10.4161/cc.6.15.4520
[PDF 913KB]

Spy1 interacts with p27Kip1 to allow G1/S progression.

Lisa A Porter, Monica Kong-Beltran, Daniel J Donoghue.
Molecular Biology of the Cell 2003 14 (9): 3664-74
doi: 10.1091/mbc.E02-12-0820
[PDF 455KB]

Human Spy1 promotes survival of mammalian cells following DNA damage.

Elizabeth A Barnes, Lisa A Porter, Jean-Luc Lenormand, Ryan W Dellinger, Daniel J Donoghue.
Cancer Research 2003 63 (13): 3701–07
[PDF 283KB]

Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis.

Lisa A Porter, Howard Cukier, Jonathan M Lee.
Blood 2003 101 (5): 1928–33
doi: 10.1182/blood-2002-04-1103
[PDF 680KB]

Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.

Nisha Anand, Sabita Murthy, Gudrun Amann, Meredith Wernick, Lisa A Porter, I Howard Cukier, Colin Collins, Joe W Gray, Joachim Diebold, Doug J Demetrick, Jonathan M Lee.
Nature Genetics 2002 31 (3): 301-5

Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2.

Lisa A Porter, Ryan W Dellinger, John A Tynan, Elizabeth A Barnes, Monica Kong, Jean-Luc Lenormand, Daniel J Donoghue.
Journal of Cell Biology 2002 157 (3): 357–66
doi: 10.1083/jcb.200109045
[PDF 360KB]

alpha-, beta-, and gamma-Tubulin polymerization in response to DNA damage.

Lisa A Porter & Jonathan M Lee.
Experimental Cell Research 2001 270 (2): 151–8
doi: http://dx.doi.org/10.1006/excr.2001.5322

Abundance of cyclin B1 regulates gamma-radiation-induced apoptosis.

Lisa A Porter, Gurmit Singh, Jonathan M Lee.
Blood 2000 95 (8): 2645–50
[PDF 184KB]


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